王富武，男，副教授，医学博士，硕士研究生导师。1998年毕业于原山东医科大学临床医学专业，获医学学士学位，2009年毕业于山东大学医学院人体解剖与组织胚胎学专业，获医学博士学位，2014.06--2015.06在美国得克萨斯州农工大学再生医学研究所进修学习。主要从事骨髓间充质干细胞发育、分化及细胞移植治疗神经系统相关疾病的研究。主持国家自然基金、山东省自然科学基金、省攻关项目及中国博士后基金等各一项，参与国家及省部级课题多项，发表SCI论文多篇，参编组织学与胚胎学教材（高教出版社）、医学形态学实验及英汉人体解剖与组织胚胎学名词、应试向导等教材数部。

承担课题：

1. TSG-6/MAPK 信号通路在褪黑素保护脑缺血后移植的骨髓间充质干细胞中的作用研究。省重点研发计划（公益类），2018.1—2019.12.31 主持

2. 活化小胶质细胞对骨髓间充质干细胞迁移、存活的作用及机制研究，国家自然科学基金（面上项目），2013.1.1--2016.12.31 主持

3. 小胶质细胞对骨髓间充质干细胞迁移的影响及其机制探讨，山东省自然科学基金（面上项目）， 2012.7.1--2015.7.31 主持

4. 炎症微环境中小胶质细胞对骨髓间充质干细胞迁移的调控作用研究，山东大学自主 创新基金项目（自然科学类），2012.1--2014.12 主持

5. 激活的小胶质细胞对骨髓间充质干细胞定向迁移的影响及其机制研究，中国博士后科学基金，2011.11—2013.11 主持

6. 妊娠糖尿病致神经管畸形发生机理的研究，国家自然科学基金， 2007.1.1-2009.12.31，第二位

7. H在神经发育中作用的研究，国家自然科学基金， 2008.1.1-2010.12.31，第二位，

8. DHHC16对胚胎端脑神经干细胞调控作用的研究，国家自然科学基金， 2013.1.1-2016.12.31，第二位，

9. 人输卵管胱硫醚-γ-裂解酶/内源性硫化氢在胚胎转运及宫外孕中的作用及机制，国家自然科学基金， 2011.1.1-2013.12.31 第三位，

10. Beta-arrestin2对海马神经干细胞初级纤毛上Shh信号通路的调控作用研究，国家自然科学基金 2013.1.1-2015.12.31，第四位，

11. 饱和脂肪酸对胚胎神经系统发育的影响及机制研究，国家自然科学基金 2013.1.1-2015.12.31，第四位，

12. Stathmin/SCLIP家族蛋白参与胶质瘤发生的生物学作用及其机制研究，山东自然科学基金， 2012.7.31-2015.7.31，第二位，

13. Oct4在脑肿瘤干细胞发生中的作用及其机制的研究，山东自然科学基金，2008.12.1-2011.12.31，第四位

14. 蛋白H在神经元蛋白棕榈酰化中作用的研究，山东自然科学基金， 2007.12.1-2010.12.31，第三位

15. 妊娠糖尿病致胚胎神经损伤作用机理的研究，教育部 2007.1.1-2009.12.30，第五位

16. 神经细胞中信号转导分子stat3的调控与功能分析，山东省奖励基金 2004.12.10-2006.12.30，第三位

近期发表的主要论文有：

Li X, Chen X, Zhou W, Ji S, Li X, Li G, Liu G, Wang F, Hao A. Effect of melatonin on neuronal differentiation requires CBP/p300-mediated acetylation of histone H3 lysine 14. Neuroscience. 2017 Nov 19;364:45-59. doi: 10.1016/j.neuroscience.2017.07.064.

Zhang Q, Liu S, Li T, Yuan L, Liu H, Wang X, Wang F, Wang S, Hao A, Liu D, Wang Z. Preconditioning of bone marrow mesenchymal stem cells with hydrogen sulfide improves their therapeutic potential. Oncotarget. 2016 Sep 6;7(36):58089-58104. doi: 10.18632/oncotarget.11166.

Chen X, Du Z, Li X, Wang L, Wang F, Shi W, Hao A. Protein Palmitoylation Regulates Neural Stem Cell Differentiation by Modulation of EID1 Activity.

Mol Neurobiol. 2016 Oct;53(8):5722-36. doi: 10.1007/s12035-015-9481-y.

Liu S, Guo Y, Yuan Q, Pan Y, Wang L, Liu Q, Wang F, Wang J, Hao A. Melatonin prevents neural tube defects in the offspring of diabetic pregnancy. J Pineal Res. 2015 Nov;59(4):508-17. doi: 10.1111/jpi.12282.

Zhang Y, Du Z, Zhuang Z, Wang Y, Wang F, Liu S, Wang H, Feng H, Li H, Wang L, Zhang X, Hao A. E804 induces growth arrest, differentiation and apoptosis of glioblastoma cells by blocking Stat3 signaling. J Neurooncol. 2015 Nov;125(2):265-75. doi: 10.1007/s11060-015-1917-8.

Wang F, Zhou H, Du Z, Chen X, Zhu F, Wang Z, Zhang Y, Lin L, Qian M, Zhang X, Li X, Hao A. Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro. Eur J Pharmacol. 2015 Feb 5;748:157-65. doi: 10.1016/j.ejphar.2014.09.033.

Guo Y, Liu S, Wang P, Zhang H, Wang F, Bing L, Gao J, Yang J, Hao A. Granulocyte colony-stimulating factor improves neuron survival in experimental spinal cord injury by regulating nucleophosmin-1 expression. J Neurosci Res. 2014 Jun;92(6):751-60.

Chen X, Shi W, Wang F, Du Z, Yang Y, Gao M, Yao Y, He K, Wang C, Hao A. Zinc finger DHHC-type containing 13 regulates fate specification of ectoderm and mesoderm cell lineages by modulating Smad6 activity. Stem Cells Dev. 2014 Aug 15;23(16):1899-909. doi: 10.1089/scd.2014.0068.

Chen X, Du Z, Shi W, Wang C, Yang Y, Wang F, Yao Y, He K, Hao A. 2-Bromopalmitate modulates neuronal differentiation through the regulation of histone acetylation. Stem Cell Res. 2014 Mar;12(2):481-91. doi: 10.1016/j.scr.2013.12.010.

Wang FW, Wang Z, Zhang YM, Du ZX, Zhang XL, Liu Q, Guo YJ, Li XG, Hao AJ. Protective effect of melatonin on bone marrow mesenchymal stem cells against hydrogen peroxide-induced apoptosis in vitro. J Cell Biochem. 2013 Oct;114(10):2346-55. doi: 10.1002/jcb.24582.

Wang FW, Zhang YM, Wang Z, Liu SM, Wang LY, Zhang XL, Jia DY, Hao AJ, Wu YL. Calcitonin promotes mouse pre-implantation development: involvement of calcium mobilization and P38 mitogen-activated protein kinase activation. Reprod Domest Anim. 2013 Jun;48(3):382-9. doi: 10.1111/rda.12000.

Zhang Y, Liu Q, Wang F, Ling EA, Liu S, Wang L, Yang Y, Yao L, Chen X, Wang F, Shi W, Gao M, Hao A. Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1α. J Pineal Res. 2013 Sep;55(2):121-30. doi: 10.1111/jpi.12052.

Wang Z, Liu DX, Wang FW, Zhang Q, Du ZX, Zhan JM, Yuan QH, Ling EA, Hao AJ. L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H₂S pathway. Neuroscience. 2013 May 1;237:106-17. doi: 10.1016/j.neuroscience.2012.12.057.

Yuan Q, Zhao S, Wang F, Zhang H, Chen ZJ, Wang J, Wang Z, Du Z, Ling EA, Liu Q, Hao A. Palmitic acid increases apoptosis of neural stem cells via activating c-Jun N-terminal kinase. Stem Cell Res. 2013 Mar;10(2):257-66. doi: 10.1016/j.scr.2012.11.008.

Yuan Q, Zhao S, Liu S, Zhang Y, Fu J, Wang F, Liu Q, Ling EA, Hao A. Folic acid supplementation changes the fate of neural progenitors in mouse embryos of hyperglycemic and diabetic pregnancy. J Nutr Biochem. 2013 Jul;24(7):1202-12. doi: 10.1016/j.jnutbio.2012.09.004.

Wang J, Li G, Wang Z, Zhang X, Yao L, Wang F, Liu S, Yin J, Ling EA, Wang L, Hao A. High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes. Neuroscience. 2012 Jan 27;202:58-68. doi: 10.1016/j.neuroscience.2011.11.062.

Guo Y, Liu S, Wang P, Zhao S, Wang F, Bing L, Zhang Y, Ling EA, Gao J, Hao A. Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas. Histopathology. 2011 Oct;59(4):763-75. doi: 10.1111/j.1365-2559.2011.03993.x.

Zhang Y, Hao H, Zhao S, Liu Q, Yuan Q, Ni S, Wang F, Liu S, Wang L, Hao A. Downregulation of GRIM-19 promotes growth and migration of human glioma cells.

Cancer Sci. 2011 Nov;102(11):1991-9. doi: 10.1111/j.1349-7006.2011.02059.x.

Wang Z, Liu D, Wang F, Liu S, Zhao S, Ling EA, Hao A. Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling. Br J Nutr. 2012 Jan;107(2):229-41. doi: 10.1017/S0007114511002868.

Zhang H, Wang FW, Yao LL, Hao AJ. Microglia--friend or foe. Front Biosci (Schol Ed). 2011 Jun 1;3:869-83. Review.

Liu D, Wang Z, Liu S, Wang F, Zhao S, Hao A. Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells. Neuropharmacology. 2011 Sep;61(4):592-9. doi: 10.1016/j.neuropharm.2011.04.033.

Wang FW, Hao HB, Zhao SD, Zhang YM, Liu Q, Liu HJ, Liu SM, Yuan QH, Bing LJ, Ling EA, Hao AJ. Roles of activated astrocyte in neural stem cell proliferation and differentiation. Stem Cell Res. 2011 Jul;7(1):41-53. doi: 10.1016/j.scr.2011.03.004.

Liu S, Yuan Q, Zhao S, Wang J, Guo Y, Wang F, Zhang Y, Liu Q, Zhang S, Ling EA, Hao A. High glucose induces apoptosis in embryonic neural progenitor cells by a pathway involving protein PKCδ. Cell Signal. 2011 Aug;23(8):1366-74. doi: 10.1016/j.cellsig.2011.03.019.

Zhao S, Yuan Q, Hao H, Guo Y, Liu S, Zhang Y, Wang J, Liu H, Wang F, Liu K, Ling EA, Hao A. Expression of OCT4 pseudogenes in human tumours: lessons from glioma and breast carcinoma. J Pathol. 2011 Apr;223(5):672-82. doi: 10.1002/path.2827.