郝晶，女，医学博士，组织学与胚胎学系教授，博士生导师。2000年毕业于山东大学医学院,获医学博士学位。2002-2006年，在美国德州大学西南医学中心做博士后研究。2016-2017年，在澳洲拉筹伯大学做访问学者。主要科研方向为乳腺癌转移机制和靶向干预，以及生殖细胞发育机制的研究。主持国家和省部级课题9项，在PANS、Stem Cells、Dev Biol、Carcinogenesis等杂志发表论文30余篇，参编十三五国家级规划教材《组织学与胚胎学》两部，获得山东省科技进步二等奖和三等奖各一项、山东省高校优秀科研成果二等奖一项。

主要承担课题：

1. 血管内皮sohlh2/sirt1/NFκB信号通路对三阴性乳腺癌细胞肺转移的调控 国家自然科学基金资助(NO: 81874118)，2019.1-2022.12，主持，在研.

2. Sohlh2在卵巢癌顺铂耐药中作用和作用机制的研究 山东省重点研发计划（2019GSF107013），2019.1.1-2021.12.31，主持，在研

3. Sohlh2在乳腺癌内分泌治疗耐药中作用和作用机制的实验研究 山东省自然科学基金 面上项目ZR201702180317 2017.8-2020.6，主持，结题.

4. Sohlh2在乳腺癌干细胞形成中作用和作用机制的实验研究 山东省科技发展计划2014GSF118085 2014.1-2016.12,主持,结题.

5. Sohlh2基因敲除致小鼠卵巢原始卵泡丢失和发育障碍机制的研究 国家自然科学基金资助(NO:31071269)，2011.1-2013.12，主持，结题.

6. Sohlh2在精原干细胞分化中作用和作用机制的实验研究，国家自然科学基金资助(NO:30971653)，2010.1-2012.12，主持，结题.

7. Bmp4/smad信号通路促进原始卵泡存活和发育机制的研究,山东大学杰出青年培育基金(2010JQ003),2010.06-2012.12，主持，结题.

8．Sohlh2基因敲除致小鼠睾丸精原细胞分化阻滞机制的实验研究 国家自然科学基金资助(NO:30871405)，2009.1-2009.12，主持，结题.

代表性论文：

1. Zhang X, Liu X, Cui W, Zhang R, Liu Y, Li Y, Hao J*. Sohlh2 alleviates malignancy of EOC cells under hypoxia via inhibiting the HIF1α/CA9 signaling pathway. Biol Chem. 2020; 401(2):263-271.

2. Zhang X, Liu R, Zhao N, Ji S, Hao C, Cui W, Zhang R, Hao J*. Sohlh2 inhibits breast cancer cell proliferation by suppressing Wnt/β-catenin signaling pathway. Mol Carcinog. 2019;58(6):1008-1018.

3. Liu X, Gao Q, Zhao N, Zhang X, Cui W, Sun J, Fu J*, Hao J*. Sohlh1 suppresses glioblastoma cell proliferation, migration, and invasion by inhibition of Wnt/β-catenin signaling. Mol Carcinog. 2018;57(4):494-502.

4. Ji S, Zhang W, Zhang X, Hao C, Hao A, Gao Q, Zhang H, Sun J, Hao J*.Sohlh2 suppresses epithelial to mesenchymal transition in breast cancer via downregulation of IL-8.Oncotarget. 2016 ;7(31):49411-49424.

5. Zhang H, Hao C, Wang Y, Ji S, Zhang X, Zhang W, Zhao Q, Sun J, Hao J*.Sohlh2 inhibits human ovarian cancer cell invasion and metastasis by transcriptional inactivation of MMP9.Mol Carcinog. 2016 Jul;55(7):1127-37

6. Zhang X, Liu R, Su Z, Zhang Y, Zhang W, Liu X, Wang F, Guo Y, Li C, Hao J*.Immunohistochemical Study of Expression of Sohlh1 and Sohlh2 in Normal Adult Human Tissues.PLoS One. 2015;10(9): e0137431.

7. Zhang X, Zhang H, Gao Q, Ji S, Bing L, Hao J*. Sohlh2 inhibits the apoptosis of mouse primordial follicle oocytes via C-kit/PI3K/Akt/Foxo3a signalling pathway.Reprod Biomed Online. 2015; 30(5):514-21.

8. Zhang H, Zhang X, Ji S, Hao C, Mu Y, Sun J, Hao J*.Sohlh2 inhibits ovarian cancer cell proliferation by upregulation of p21 and downregulation of cyclin D1.Carcinogenesis. 2014; 35(8):1863-71.

9. Zhang X, Shi K, Li Y, Zhang H, Hao J*. Lipopolysaccharide inhibits the self-renewal of spermatogonial stem cells in vitro via downregulation of GDNF expression in Sertoli cells. Reprod Toxicol. 2014; 45: 87-93.

10. Li Y, Zhang Y, Zhang X, Sun J, Hao J*.BMP4/Smad signaling pathway  induces the differentiation of mouse spermatogonial stem cells via upregulation of Sohlh2.Anat Rec (Hoboken). 2014; 297(4):749-57.

11. Ding X, Zhang X, Mu Y, Li Y, Hao J*. Effects of BMP4/SMAD signaling pathway on mouse primordial follicle growth and survival via up-regulation of Sohlh2 and c-kit. Mol Reprod Dev. 2013; 80(1):70-8.

12. Li Y, Gao Q, Yin G, Ding X, Hao J*.WNT/β-Catenin-Signaling Pathway Stimulates the Proliferation of Cultured Adult Human Sertoli Cells via Upregulation of C-myc Expression.Reprod Sci. 2012; 19(11):1232-40.

13. Zhang S, Li Y, Wu Y, Shi K, Bing L, Hao J*. Wnt/β-Catenin Signaling Pathway Upregulates c-Myc Expression to Promote Cell Proliferation of P19 Teratocarcinoma Cells. Anat Rec (Hoboken). 2012; 295(12): 2104-13.

14. Hao J, Yamamoto M, Richardson TE, Chapman KM, Denard BS,Hammer RE, Zhao GQ, and Hamra FK*. Sohlh2 knockout mice are male-sterile because of degeneration of differentiating type A spermatogonia. Stem Cells. 2008; 26(6):1587-97.

15. Hao J, Li TG, Qi X, Zhao DF, and Zhao GQ*. WNT/catenin pathway upregulates Stat3 and converges on LIF to prevent differentiation of embryonic stem cells. Dev Biol.2006; 290, 81-91.

16. Qi X, Li TG, Hao J, Hu J, Wang J, Simmons H, Mishina Y, and Zhao GQ*. BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase (MAPK) pathways. Proc. Natl. Acad. Sci. USA 2004; 101, 6027-6032. (co-first-author)

 * 通讯作者

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Email: haojing@sdu.edu.cn