郝爱军，博士，教授，博士生导师，先后毕业于山东医科大学和新加坡国立大学，获得神经科学博士学位。山东省杰出青年基金和教育部新世纪优秀人才支持计划获得者。主要从事神经发育及相关疾病中作用及机制的研究，重点关注神经干细胞的增殖分化调控机制研究和神经发育相关疾病的治疗研究，以及神经发育相关精神疾病的遗传及分子机制。利用斑马鱼和小鼠等模式动物建立了多种神经发育异常及损伤模型，结合神经干细胞及其他神经细胞类型，深入探究转录因子及小分子在发育及疾病中的作用机制。获得国家及省部级课题多项，在Journal of Pineal Research、Glia、Cell death & disease、Stem cell research & therapy、Stem cells and development、Journal of biological chemistry等杂志发表多篇SCI论文。

社会兼职

山东省解剖学会副理事长，美国神经科学协会会员（The American Society for Neuroscience）,美国细胞生物学协会会员（The American Society for Cell Biology）。

主持或参加科研项目及人才计划项目情况（按时间倒序排序）：

1. 国家自然科学基金，82071267，星形胶质细胞TOX3调控髓鞘发育的新发现及机制研究，主持

2. 国家自然科学基金，81771219，TOX3在原发性小头畸形发生中的作用及机制研究，主持

3. 山东省重点研发计划, 2018GSF118076, TOX3在大脑皮层发育缺陷中的作用机制研究及对认知功能障碍的影响，主持

4. 国家自然科学基金，81571093，Sox19b在神经管发育缺陷中的新作用及机制研究，主持

4. 国家自然科学基金，31440056，小分子化合物对胚胎神经干细胞作用的新发现及机制研究，主持

5. 国家自然科学基金，31271289，DHHC16对胚胎端脑NSCs调控作用的研究， 主持

6. 国家自然科学基金，81071057，G-CSF 对脑瘫内源性NSCs的作用及作用机制研究，主持

7. 国家自然科学基金（面上项目）, 30771142, 蛋白H 在神经发育中作用的研究，主持

8. 山东省杰出青年基金，JQ200823，Oct4 在NSCs正常及异常发生中的作用及其机制的研究，主持

9. 国家自然科学基金, 30671105, 妊娠糖尿病致神经管畸形发生机理的研究，主持

10. 山东省自然科学基金重点项目, Z2007C11, 蛋白H在神经元蛋白棕榈酰化中作用的研究，已结题，主持

11. 新世纪优秀人才支持计划

12. 曾获国际脑科学研究组织(The international Brain Research Organization),国际发育神经生物学学会(The International Society For Developmental)，欧洲健康和疾病研究会(European Society for cell Function in Health)和新加坡李氏基金(Lee Foundation, Singapore)的资助和奖励。曾主持新加坡国立大学的重要科研项目Molecular and morphological analysis of Neural Tube Defects in Embryos of Diabetic and Retinoic Acid Treated Rats(R-181-000-027-112) 和新加坡医学研究委员会重要科研项目Analysis of Regulatory Factor Involved in Neurdoxicing in Neurodegeneratine Disease(R-181-000-058-213) 。

近期发表的主要论文有：

1.Xinyue Li, Guangyu Ji, Juan Zhou, Jingyi Du, Xian Li, Wei Shi, Yong Hu, Wenjuan Zhou, Aijun Hao(*), Pcgf1 Regulates Early Neural Tube Development Through Histone Methylation in Zebrafish. Front Cell Dev Biol, 2021 Jan 26; 8:581636.

2.Xu Wang, Wenjuan Zhou, Xian Li, Jun Ren, Guangyu Ji, Jingyi Du, Wenyu Tian, Qian Liu, Aijun Hao(*), Graphene oxide suppresses the growth and malignancy of glioblastoma stem cell-like spheroids via epigenetic mechanisms. Journal of Translational Medicine, 2020 May 14;18(1):200.

3. Li, Xian, Zhou, Wenjuan, Li, Xinyue, Gao, Ming, Tian, Wenyu, Ji, Shufang, Du, Jing yi, Hao, Aijun(*), SOX19b regulates the premature neuronal differentiation of neural st em cells through EZH2-mediated histone methylation in neural tube development of ze brafish. Stem cell research & therapy, 2019 Dec 16;10(1):389.

4. Ji, Shufang, Zhou, Wenjuan, Li, Xian, Liu, Shangming, Wang, Fuwu, Li, Xinyue, Zhao, Tiantian, Ji, Guangyu, Du, Jingyi, Hao, Aijun(*). Maternal hyperglycemia disturbs neocortical neurogenesis via epigenetic regulation in C57BL/6J mice. Cell Death and Disease. 2019 Mar 1;10(3):211.

5. Zhou, Wenjuan, Zhao, TianTian, Du, JingYi, Ji, GuangYu, Li, Xian, Ji, ShuFang, Tian, WenYu, Wang, Xu, Hao, Aijun(*), TIGAR promotes neural stem cell differentiation through acetyl-CoA-mediated histone acetylation. 2019 Feb 27;10(3):198.

6. Li, Xian, Chen, Xueran, Zhou, Wenjuan, Ji, Shufang, Li,Xinyue, Li,Guanchong, Liu, Guowei, Wang, Fuwu, Hao, Aijun^(*), Effect of melatonin on neuronal differentiation requires CBP/p300-mediated acetylation of histone H3 lysine 14. Neuroscience. 2017 Aug 4. pii: S0306-4522(17)30550-X.

7. Chen, Xueran, Du, Zhaoxia, Li, Xian, Wang, Liyan, Wang, Fuwu, Shi, Wei, Hao, Aijun(*), Protein Palmitoylation Regulates Neural Stem Cell Differentiation by Modulation of EID1 Activity. Molecular Neurobiology. 2016.10.01，53（8）：5722~5736

8. Shi Wei，Chen Xueran，Wang Fen，Gao Ming，Yang Yang，Du Zhaoxia，Wang Chen，Yao Yao，He Kun，Hao Aijun(*), ZDHHC16 Modulates FGF/ERK Dependent Proliferation of Neural Stem/Progenitor Cells in the Zebrafish Telencephalo, Developmental Neurobiology，2016.9.3，76（9）：1014~1028

9. Du, Zhaoxia, Chen, Xueran(*), Li, Xian, He, Kun, Ji, Shufang, Shi,Wei, Hao, Aijun(*)，Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Biochemical and Biophysical Research Communications，2016.6.24，475：194~201

10. Guo Yuji, Liu Shangming, Zhang Xianghong, Wang Liyan, Gao Jiangang, Han Aiqing(*), Hao Aijun (*), G-CSF promotes autophagy and reduces neural tissue damage after spinal cord injury in mice. Laboratory Investigation，2015.12.1，95：1439~1449

11. Wang Fen，Chen Xueran，Shi Wei，Yao Linli，Gao Ming，Yang Yang，Hao Aijun(*)，Zdhhc15b Regulates Differentiation of Diencephalic Dopaminergic Neurons in Zebrafish. Journal of Cellular Biochemistry，2015.12.01，116：2980~2991

12. Liu, Shangming，Guo, Yuji，Yuan, Qiuhuan，Pan, Yan，Wang, Liyan，Liu, Qian，Wang, Fuwu，Wang, Jingjing(*) , Hao, Aijun(*)， Melatonin prevents neural tube defects in the offspring of diabetic pregnancy. Journal of Pineal Research，2015.11.01，59：508~517

13. Shi Wei，Wang Fen，Gao Ming，Yang Yang，Du Zhaoxia，Wang Chen，Yao Yao，He Kun，Chen Xueran(*)，Hao Aijun(*)， ZDHHC17 promotes axon outgrowth by regulating TrkA–tubulin complex formation. Molecular and Cellular Neuroscience，2015.9.01，68：194~202

14. Chen Wang，Xueran Chen，Wei Shi，Fen Wang，Zhaoxia Du，Xian Li，Yao Yao，Tong Liu，Tong Shao，Gang Li，Hao Aijun(*)，2-Bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Neurotoxicology and Teratology，2015.7.01，50：53~63

15. Wang, Fuwu，Zhou, Huaiyu，Du, Zhaoxia，Chen, Xueran，Zhu, Faliang，Wang, Zhen，Zhang, Yanmin，Lin, Lin，Qian, Mingyu，Zhang, Xianghong，Li, Xingang(*), Hao, Aijun(*)，Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro. European Journal of Pharmacology，2015.2.5，748：157~165

16. Zhang yanmin，Ni Shilei，Huang Bin，Wang Liyan，Zhang Xianghong，Li Xian，Wang Han，Liu Shuai，Hao Aijun(*), Li Xingang(*)， Overexpression of SCLIP promotes growth and motility in glioblastoma cells. Cancer Biol Ther.，2015.1.1，16：97~105

17. Chen X, Shi W, Wang F, Du Z, Yang Y, Gao M, Yao Y, He K, Wang C, Hao A*. Zinc finger DHHC-type containing 13 regulates fate specification of ectoderm and mesoderm cell lineages by modulating Smad6 activity. Stem Cells Dev, 2014, 23(16):1899-1909.

18.Chen X, Du Z, Shi W, Wang C1, Yang Y, Wang F, Yao Y, He K, Hao A*. 2-Bromopalmitate modulates neuronal differentiation through the regulation of histone acetylation. Stem Cell Res, 2014, 12(2):481–491.

19. Chen X, Li X, Du Z, Shi W, Yao Y, Wang C, He K, Hao A*. Melatonin promotes the acquisition of neural identity through extracellular-signal-regulated kinases 1/2 activation. Journal of Pineal Research, 2014, 57(2):168–176

20. Liu, D., Wang, Z., Zhan, J., Zhang, Q., Wang, J., Xian, X., Luan, Q., and Hao, A*. Hydrogen sulfide promotes proliferation and neuronal differentiation of neural stem cells and protects hypoxia-induced decrease in hippocampal neurogenesis. Pharmacol Biochem Behav ,2014,116, 55-63.

21. Wang, Z., Liu, D., Zhang, Q., Wang, J., Zhan, J., Xian, X., Du, Z., Wang, X., and Hao, A*. Palmitic acid affects proliferation and differentiation of neural stem cells in vitro. J Neurosci Res, 2014.

22. Zhang Y, Liu Q, Wang F, Ling EA, Liu S, Wang L, Yang Y, Yao L, Chen X, Wang F, Shi W, Gao M, Hao A*. Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1α. J Pineal Res. 2013 Sep;55 (2):121-30. doi: 10.1111/jpi.12052. Epub 2013 Mar 29.